Digitalis and strophanthus---cardiac glycosides
نویسندگان
چکیده
منابع مشابه
DIGITALIS & RELATED CARDIAC GLYCOSIDES Background
in the following notes the term digitalis is used to describe the entire group of cardiac glycosides a large number of plants contain cardiac glycosides, and these have been used by natives as arrow and ordeal poisons Squill was known to the ancient Egyptians and the Romans used it as a diuretic, heart tonic, emetic and rat poison Strophanthus was introduced by Sir Thomas Fraser in 1890 digital...
متن کاملPhenylethanoid Glycosides from Digitalis viridiflora
From the MeOH extract of the leaves of Digitalis viridiflora five phenylethanoid glycosides (1-5) including a new one were isolated. The structure of the new compound was established as 3,4-dihydroxy-βphenylethoxy-O-β-quinovopyranosyl-(16)-4-O-caffeoyl-β-glucopyranoside (viridifloroside, 1) based on extensive 1Dand 2D-NMR spectroscopy as well as MS. Compound 1 is the first example of a phenyle...
متن کاملSome Distinguishing Features of a Few Strophanthus Species
Strophanthus (Family apocynaceae) contains glycosides which are comparable with cardiac glycosides of Digitalis but has less harmful physiological actions, S. kombe Oliver is officially used but some other species of this genus also contain glycosides and resemble the official one and thus often used as adulterants, This study shows distinguishing features of some strophanthus species.
متن کاملCardiac glycosides and isoforms of Na/K-ATPase 1 Selectivity of digitalis glycosides for isoforms of human Na,K-ATPase
There are four isoforms of the α subunit (α1-4) and three isoforms of the β subunit (β1-3) of Na,K-ATPase, with distinct tissue-specific distribution and physiological functions. α2 is thought to play a key role in cardiac and smooth muscle contraction and be an important target of cardiac glycosides. An α2selective cardiac glycoside could provide important insights into physiological and pharm...
متن کاملAcute hypertensive effect of digitalis glycosides.
reentrant tachycardia. Micro-reentry within the peripheral ramifications of the Purkinje system, and at Purkinje fiber-ventricular muscle junctions has been demonstrated in a variety of experimental preparations.13-l5 In each case the essential requirement has been the establishment of inhomogeneous conduction and unidirectional block. The arrhythmias generated in these laboratory models have a...
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ژورنال
عنوان ژورنال: Heart
سال: 1998
ISSN: 1355-6037
DOI: 10.1136/hrt.80.1.4